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Near infrared dye-labelled polymeric micro- and nanomaterials: in vivo imaging and evaluation of their local persistence

Abstract

The use of micro- and nanomaterials as carriers of therapeutic molecules can enhance the efficiency of treatments while avoiding side effects thanks to the development of controlled drug delivery systems. The binding of a dye to a drug or to a drug-carrier has opened up a wide range of possibilities for an effective in vivo optical tracing of drug biodistribution by using non-invasive real-time technologies prior to their potential use as therapeutic vectors. Here, we describe the fluorescent tagging of polymeric micro- and nanomaterials based on poly(lactic-co-glycolic) acid and on the thermoresponsive poly(N-isopropylacrylamide) with the fluorescent probe IR-820 which was chemically modified for its covalent coupling to the materials. The chemical modification of the dye and the polymers yielded micro- and nanoparticulated labeled-materials to be potentially used as drug depots of different therapeutic molecules. In vitro biological studies reveal their reduced cytotoxicity. A spatiotemporal in vivo micro- and nanoparticle tracking allowed the evaluation of the materials biodistribution showing their local persistence and high biocompatibility after pathological studies. These results underline the suitability of those materials for the local, sustained, not harmful and/or on-demand drug delivery and the remarkable importance of evaluating materials biodistribution and tissue persistence for their use as local drug depots.

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Publication details

The article was received on 02 Oct 2017, accepted on 02 Jan 2018 and first published on 02 Jan 2018


Article type: Paper
DOI: 10.1039/C7NR07345C
Citation: Nanoscale, 2018, Accepted Manuscript
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    Near infrared dye-labelled polymeric micro- and nanomaterials: in vivo imaging and evaluation of their local persistence

    G. Mendoza, I. Ortiz de Solorzano , I. C. Pintre, S. Garcia-Salinas, V. Sebastian, V. Andreu, M. Gimeno and M. Arruebo, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C7NR07345C

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