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Dextran-coated iron oxide nanoparticle-improved therapeutic effects of human mesenchymal stem cells in a mouse model of Parkinson’s disease

Abstract

Parkinson’s disease (PD) is a prevalent neurodegenerative disease characterized by the loss of dopaminergic (DA) neurons. With the migration capacity toward the sites of diseased DA neurons in the PD brain, mesenchymal stem cells (MSCs) have the potential to differentiate to DA neurons for the replacement of damaged neurons and to secret neurotrophic factors for the protection and regeneration of diseased DA neurons, and therefore MSCs have shown promise for the treatment of PD. In the study, for the first time, we demonstrate that dextran-coated iron oxide nanoparticles (Dex-IO NPs) can improve the therapeutic efficacy of human MSCs (hMSCs) in a mouse model of PD induced by local injection of 6-hydroxydopamine (6-OHDA). In situ examinations not only show that Dex-IO NPs can improve the rescue effect of hMSCs on the loss of host DA neurons but also demonstrate that Dex-IO NPs can promote the migration capacity of hMSCs toward lesioned DA neurons and induce the differentiation of hMSCs to DA-like neurons at the diseased sites. In vitro we prove that Dex-IO NPs can enhance the migration of hMSCs toward 6-OHDA-damaged SH-SY5Y-derived DA-like cells, induce hMSCs to differentiate to DA-like neurons under the conditioned media derived from 6-OHDA-dameged SH-SY5Y-derived DA-like cells and promote the protection/regeneration effects of hMSCs on 6-OHDA-damaged SH-SY5Y-derived DA-like cells. We confirm the potential of MSCs for cell-based therapy for PD. Dex-IO NPs can be used as a tool to accelerate and optimize MSCs therapeutics for PD applicable clinically.

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Supplementary files

Publication details

The article was received on 19 Sep 2017, accepted on 02 Jan 2018 and first published on 02 Jan 2018


Article type: Paper
DOI: 10.1039/C7NR06976F
Citation: Nanoscale, 2018, Accepted Manuscript
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    Dextran-coated iron oxide nanoparticle-improved therapeutic effects of human mesenchymal stem cells in a mouse model of Parkinson’s disease

    T. Chung, S. Hsu, S. Wu, J. Hsiao, C. Lin, M. Yao and D. Huang, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C7NR06976F

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