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Dually responsive gold-iron oxide heterodimers: merging stimuli-responsive surface properties to intrinsic inorganic material features

Abstract

We demonstrate a versatile approach for the preparation of dually responsive smart inorganic heterostructures (HSs) with exploitation in nanomedicine. We utilize Au-FexOy dimers as templates for generating smart inorganic HSs with a pH and a thermo-responsive coating attached to the iron oxide and gold nanoparticles (NPs), respectively. First, a thiol-modified thermo-responsive (PNIPAAM-co-PEGA) polymer could be selectively attached to the gold domain by ligand exchange. The sequential attachment of a catechol-modified initiator to the iron oxide surface enables the in situ polymerization of a pH-responsive (PDMAEA) polymer. As hereby shown, the presence of the two distinct polymer domains on each NP subdomains enables each side of the HS to be loaded with different agents. Indeed, by a gel electrophoresis experiment we demonstrate the loading of siRNA on the pH-responsive polymer and the loading of Nile blue dye, used as a drug model molecule, on the thermo-responsive polymer. The smart HSs exhibited good biocompatibility and it downregulated the GFP production when loaded with anti-GFP siRNA molecules. In addition, an investigation of the magnetic relaxivity times revealed that the high R2 relaxivity values of the HSs suggests their potential as contrast agents in magnetic resonance imaging (MRI) applications.

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Publication details

The article was received on 09 Sep 2017, accepted on 28 Dec 2017 and first published on 08 Jan 2018


Article type: Paper
DOI: 10.1039/C7NR06726G
Citation: Nanoscale, 2018, Accepted Manuscript
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    Dually responsive gold-iron oxide heterodimers: merging stimuli-responsive surface properties to intrinsic inorganic material features

    H. Kakwere, M. Materia, A. Curcio, M. Prato, S. Ayyappan, S. Nitti and T. Pellegrino, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C7NR06726G

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