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Issue 4, 2018
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High-efficiency X-ray luminescence in Eu3+-activated tungstate nanoprobes for optical imaging through energy transfer sensitization

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Abstract

X-ray luminescence optical imaging has been recognized as a powerful technique for medical diagnosis due to its deep penetration and low auto-fluorescence in tissues. However, the low luminescence efficiency of current X-ray luminescence nanoprobes remains a major hurdle for sensitive bioimaging in practical medical applications. Here we present a new kind of energy transfer-sensitized X-ray luminescence nanoprobe (PEG-NaGd(WO4)2:Eu) for highly effective optical bioimaging. Under X-ray excitation, the tungstate host absorbs the X-ray photons and then transfers the energy to the Eu3+ luminescence center, thus enhancing the luminescence efficiency of the nanoprobes for high sensitivity optical in vivo imaging. Moreover, the shortened T1 relaxation response of Gd3+ ions and X-ray attenuation capability of W atoms enable the nanoprobes to serve as efficient contrast agents for magnetic resonance imaging (MRI) and computed tomography (CT) imaging. Therefore, combined with the MRI, CT and X-ray luminescence imaging capabilities, the present PEG-NaGd(WO4)2:Eu nanoprobes could be used as promising multimodal imaging contrast agents in biological systems.

Graphical abstract: High-efficiency X-ray luminescence in Eu3+-activated tungstate nanoprobes for optical imaging through energy transfer sensitization

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Publication details

The article was received on 28 Aug 2017, accepted on 13 Dec 2017 and first published on 20 Dec 2017


Article type: Communication
DOI: 10.1039/C7NR06405E
Citation: Nanoscale, 2018,10, 1607-1612
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    High-efficiency X-ray luminescence in Eu3+-activated tungstate nanoprobes for optical imaging through energy transfer sensitization

    T. Guo, Y. Lin, W. Zhang, J. Hong, R. Lin, X. Wu, J. Li, C. Lu and H. Yang, Nanoscale, 2018, 10, 1607
    DOI: 10.1039/C7NR06405E

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