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Following the electrons: peculiarities in the catalytic cycles of radical SAM enzymes

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Abstract

Radical SAM enzymes use S-adenosyl-L-methionine as an oxidant to initiate radical-mediated transformations that would otherwise not be possible with Lewis acid/base chemistry alone. These reactions are either redox neutral or oxidative leading to certain expectations regarding the role of SAM as either a reusable cofactor or the ultimate electron acceptor during each turnover. However, these expectations are frequently not realized resulting in fundamental questions regarding the redox handling and movement of electrons associated with these biological catalysts. Herein we provide a focused perspective on several of these questions and associated hypotheses with an emphasis on recently discovered radical SAM enzymes.

Graphical abstract: Following the electrons: peculiarities in the catalytic cycles of radical SAM enzymes

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Publication details

The article was received on 05 Dec 2017 and first published on 27 Feb 2018


Article type: Viewpoint
DOI: 10.1039/C7NP00058H
Citation: Nat. Prod. Rep., 2018, Advance Article
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    Following the electrons: peculiarities in the catalytic cycles of radical SAM enzymes

    Mark W. Ruszczycky, A. Zhong and H. Liu, Nat. Prod. Rep., 2018, Advance Article , DOI: 10.1039/C7NP00058H

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