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Issue 14, 2018
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Isocyanide based multicomponent click reactions: a green and improved synthesis of 1-substituted 1H-1,2,3,4-tetrazoles

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Abstract

An improved ultrasound assisted green synthesis of 1-substituted 1H-1,2,3,4-tetrazoles via a novel isocyanide based multicomponent click reaction (IMCCR) under mild, solvent, catalyst and column-free conditions has been developed. This new, green and sustainable IMCCR methodology resulted in good to excellent yields (71–97%) in shorter reaction times.

Graphical abstract: Isocyanide based multicomponent click reactions: a green and improved synthesis of 1-substituted 1H-1,2,3,4-tetrazoles

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Publication details

The article was received on 10 May 2018, accepted on 11 Jun 2018 and first published on 12 Jun 2018


Article type: Letter
DOI: 10.1039/C8NJ02312C
Citation: New J. Chem., 2018,42, 11294-11298
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    Isocyanide based multicomponent click reactions: a green and improved synthesis of 1-substituted 1H-1,2,3,4-tetrazoles

    S. G. Pharande, M. A. Rentería-Gómez and R. Gámez-Montaño, New J. Chem., 2018, 42, 11294
    DOI: 10.1039/C8NJ02312C

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