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Synthesis, surface properties and temperature dependence of phase separation of DSPE chains in ethanol solutions

Abstract

A novel renewable dehydroabietic acid trimethylolpropane ester (DATE) and dehydroabietic-based succinic acid polyester (DSPE) were successfully preparedin a facile way.Various analytical techniques were employed to evaluate the chemical structure of the ester and the polymer. The monomer and polymer can form stable micelles with low critical micelle concentrations (CMC), the CMC values are 0.0026 and 0.0019 mg/mL for DATE and DSPE in ethanol respectively. In addition, the aggregation and dissociation of DSPE chains in ethanol solutions during one cycle heating and cooling process were detected. The results indicated that DSPE chains aggregate during cooling. In contrast, during heating, the aggregates dissociated gradually and distinct hysteresis occurred. Moreover, kinetics of phase separation of DSPE/ethanol solution was monitored, apparent activation energy of phase separation of the DSPE/ethanol solution was estimated by kinetics analysis.The results showed that DSPE with low CMC and temperature-dependent behavior may have tremendous scope as drug carrier in the area of controlled drug delivery.

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Publication details

The article was received on 13 Apr 2018, accepted on 15 May 2018 and first published on 17 May 2018


Article type: Paper
DOI: 10.1039/C8NJ01781F
Citation: New J. Chem., 2018, Accepted Manuscript
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    Synthesis, surface properties and temperature dependence of phase separation of DSPE chains in ethanol solutions

    J. Zhou, Y. Lan, F. Lei, Y. Zhao, J. Lu, Q. Huang, P. Li, H. Li and J. Zhang, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ01781F

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