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Issue 13, 2018
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Real-time probing of mercury using an efficient “turn-on” strategy with potential as in-field mapping kit and in live cell imaging

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Abstract

Based on a rhodamine scaffold as a fluorophore and 2-aminothiazole as a receptor, we present a highly selective and sensitive sensor (TS). An enhanced photophysical response (fluorescence as well as absorption) accompanied by high sensitivity and selectivity was observed upon interaction of TS with Hg2+ among various competitive cations (Ag+, Al3+, Ba2+, Ca2+, Co3+, Co2+, Cd2+, Fe3+, Fe2+, K+, Li+, Mg2+, Mn2+, Cu2+, Pb2+, Ni2+, Na+ and Zn2+) in CH3CN : H2O (7 : 3 v/v, HEPES buffer 10 mM pH 7.0). The synthesized sensor can detect Hg2+ as low as 0.326 μM with a complexation constant of 2.37 × 106 M−1. This complexation between TS and Hg2+ is reversible in the presence of ethylenediaminetetraacetate (EDTA). Furthermore, single crystal X-ray diffraction (XRD) and Job's plot results show a 1 : 1 binding stoichiometry. The most interesting feature of the sensor is the real-time determination of Hg2+ in real contaminated water. Furthermore, the fabricated sensor can be employed as an intracellular monitoring agent for live cell imaging of the HeLa cell line.

Graphical abstract: Real-time probing of mercury using an efficient “turn-on” strategy with potential as in-field mapping kit and in live cell imaging

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Publication details

The article was received on 11 Apr 2018, accepted on 15 May 2018 and first published on 16 May 2018


Article type: Paper
DOI: 10.1039/C8NJ01746H
Citation: New J. Chem., 2018,42, 10940-10946
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    Real-time probing of mercury using an efficient “turn-on” strategy with potential as in-field mapping kit and in live cell imaging

    T. Rasheed, C. Li, F. Nabeel, M. Qi, Y. Zhang and C. Yu, New J. Chem., 2018, 42, 10940
    DOI: 10.1039/C8NJ01746H

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