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Selective recognition of atropine in biological fluids and leaves of Datura stramonium employing carbon nanotubes – chitosan film based biosensor

Abstract

This paper demonstrates a selective, expeditious and facile electrochemical approach for the ultrasensitive detection of atropine in complex matrices. Herein, a non-destroyable surface decoration of single walled carbon nanotubes with biopolymer chitosan composite film coated on a glassy carbon electrode has been employed for the first time for the determination of atropine. The biosensor exhibited notable stability and uniformity in the composite film, short response time, exemplary reproducibility and an excellent catalytic activity towards the electro oxidation of atropine leading to a significant improvement in response sensitivity. The linearity in the calibration curve for atropine concentration was observed under the optimized conditions, in the range from 100 nM – 150 µM with the limits of quantification and detection as 54.9 and 16.5 nM, respectively. High recognition selectivity was showcased by the developed biosensor which was efficaciously applied to determine atropine in commercially available pharmaceuticals. The biosensor was further adequately implemented for the quantitation of atropine in media of human serum and urine samples with satisfied recovery. Additionally, the practical analytical performance of the biosensor was investigated by assessing the selective detection of atropine in the leaves of Datura stramonium.

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Publication details

The article was received on 17 Mar 2018, accepted on 17 Apr 2018 and first published on 08 May 2018


Article type: Paper
DOI: 10.1039/C8NJ01312H
Citation: New J. Chem., 2018, Accepted Manuscript
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    Selective recognition of atropine in biological fluids and leaves of Datura stramonium employing carbon nanotubes – chitosan film based biosensor

    S. Mane, R. Narmawala and S. Chatterjee, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ01312H

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