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Xerogel modified diatomaceous earth microparticles for controlled drug release studies

Abstract

Naturally available diatomaceous earth (DE) microparticles are one of the ideal candidates for drug delivery due to their excellent features like biocompatibility, non-toxicity, porosity, high surface area and ease of surface modification. On the other hand, they have some limitations especially in drug delivery applications such as poor drug loading capacity and very high initial burst release. In order to address these drawbacks, we have surface modified the diatoms with silica xerogel which forms a novel hybrid material. Modification process was carried out by a facile sol-gel method, the silica xerogel decorated DE were extensively characterized by SEM, BET, ATR-IR and XRD in order to confirm covalent linkage of new material on the surface of DE. The prepared hybrid material DE-XER (xerogel) acts as a pH-sensitive micro drug carrier for diclofenac sodium (DS) drug. Results indicate that the surface modification plays a critical role which enhances the drug loading capacity in comparison with neat DE, achieving effective controlled release. Furthermore, the obtained drug release data were fitted to zero order model to understand the drug release mechanism.

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Publication details

The article was received on 13 Mar 2018, accepted on 05 Jun 2018 and first published on 07 Jun 2018


Article type: Paper
DOI: 10.1039/C8NJ01238E
Citation: New J. Chem., 2018, Accepted Manuscript
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    Xerogel modified diatomaceous earth microparticles for controlled drug release studies

    U. UT, S. G, V. Brahmkhatri, M. Kigga, H. Jung, T. Altalhi, G. M. Neelgund and M. Kurkuri, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ01238E

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