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Issue 13, 2018
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A pyrazoline-based fluorescent chemosensor for Al3+ ion detection and live cell imaging

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Abstract

Two pyrene-appended pyrazoline compounds (PY-I and PY-II) were designed and synthesized. Their photophysical properties were studied by absorption and fluorescence spectral studies. PY-I displays an excellent selective and sensitive response to Al3+ ions over other metal ions, whereas PY-II did not respond to any metal ions. A 1 : 1 stoichiometry for the PY-I–Al3+ complex was observed with an association constant of 2.13 × 103 M−1. Furthermore, PY-I was employed for fluorescence imaging of Al3+ ions in living cells. PY-I has a phenolic group as a binding site at the 3-position of the pyrazoline ring which is responsible for its sensing of metal ions. Nevertheless, PY-II has no hydroxyl groups in the phenyl ring and was unable to sense metal ions; however, PY-II has good photophysical properties which make it a suitable fluorescent material.

Graphical abstract: A pyrazoline-based fluorescent chemosensor for Al3+ ion detection and live cell imaging

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Publication details

The article was received on 12 Mar 2018, accepted on 22 Apr 2018 and first published on 11 May 2018


Article type: Paper
DOI: 10.1039/C8NJ01211C
Citation: New J. Chem., 2018,42, 10891-10897
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    A pyrazoline-based fluorescent chemosensor for Al3+ ion detection and live cell imaging

    M. Rangasamy and K. Palaninathan, New J. Chem., 2018, 42, 10891
    DOI: 10.1039/C8NJ01211C

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