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Exploration of fluorescent organotin compounds of α-amino acid Schiff bases for the recognition of organophosphorous chemical warfare agents: Quantification of diethylchlorophosphate

Abstract

Herein, fluorescent di-methyltin(IV) compounds (1-4) of an azomethinic ligating system derived from template assisted condensation of α-amino acids (i.e. L-alanine, L-leucine, L-glutamine, L-isoleucine) and 2-hydroxybenzaldehyde are reported. The synthesized di-methyltin derivatives were characterized by FT-IR spectroscopy, multi-nuclei NMR (1H, 13C and 119Sn) spectroscopy, mass spectrometry and single crystal X-ray diffraction. The compounds 1-4 exhibited fluorescence emission centred at 470 nm when excited at a wavelength of 360 nm. The emission band experienced quenching in the presence of various organophosphates, therefore, a representative compound was explored for the fluorogenic chemo-sensing of various organophosphates. The fluorescence response was found maximum for diethylchlorophosphate (a potential mimic of chemical warfare agents) and offered detection up to 0.023 mM. To explore the practicality of the test compound, it was successfully incorporated into portable devices of variable designs, like fluorescent strips and silica tablets, for the on-spot detection of chemical warfare agents.

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Publication details

The article was received on 09 Mar 2018, accepted on 09 Apr 2018 and first published on 10 Apr 2018


Article type: Paper
DOI: 10.1039/C8NJ01153B
Citation: New J. Chem., 2018, Accepted Manuscript
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    Exploration of fluorescent organotin compounds of α-amino acid Schiff bases for the recognition of organophosphorous chemical warfare agents: Quantification of diethylchlorophosphate

    N. Singh, K. Makkar, N. Srivastav, R. Singh, V. KAUR, J. P. Jasinski and R. J. Butcher, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ01153B

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