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Determination of pH-independent rate constants of thiolate–disulfide redox transitions

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Abstract

Microscopic rate constants were introduced and determined to quantify thiolate–disulfide kinetics of biological significance. The highly composite, codependent acid–base and redox processes of thiols could so far be characterized only in terms of apparent equilibrium and rate constants. A tailor-made evaluation method is elaborated with the use of quantitative NMR measurements to follow the kinetics of the forward and reverse reactions between mercaptoethanol and cystamine. The microscopic rate constants, which are new, pH-independent parameters, correlate nicely with the respective reactant structures and chemical characteristics. The reported rate constant values also allow a better understanding and prediction of thiolate–disulfide redox transitions.

Graphical abstract: Determination of pH-independent rate constants of thiolate–disulfide redox transitions

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Publication details

The article was received on 01 Mar 2018, accepted on 04 Jun 2018 and first published on 07 Jun 2018


Article type: Paper
DOI: 10.1039/C8NJ01015C
Citation: New J. Chem., 2018, Advance Article
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    Determination of pH-independent rate constants of thiolate–disulfide redox transitions

    A. Mirzahosseini, Z. Faragó and B. Noszál, New J. Chem., 2018, Advance Article , DOI: 10.1039/C8NJ01015C

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