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Natural Solvent-Assisted Synthesis of Amphiphilic Co-Polymeric Nanomicelle for Prolonged Release of Camptothecin Delivery

Abstract

Biomaterials developed using sustainable methods and non-toxic solvents are effectively applied as eco-friendly, sustainable reaction medium and catalysts for biological applications. This work describes the development of ε-caprolactone-citric acid nanomicelle using deep eutectic solvents (DESs) in the form of choline chloride and citric acid. The solvent formation is confirmed by FT-IR and 1H NMR spectroscopy. The highest polycondensation of ε-caprolactone (ε-cp) with citric acid (CA) poly (ε-cp-co-CA) occurs in the1:2 DES medium. Camptothecin (CPT), used as a model anticancer agent, is encapsulated by poly (ε-cp-co-CA) micelle, which act as drug carriers. Micelle formation is determined by fluorescence analysis using pyrene (CMC=0.5 mg/mL) molecule. The self-assembled CPT-loaded poly (ε-cp-co-CA) micelle is characterized by FT-IR, XRD, SEM, and TEM techniques. The size of the nanomicelle is observed to be ≈270 nm by dynamic light scattering (DLS) techniques. The encapsulation efficiency and in-vitro profiles of CPT in poly (ε-cp-co-CA) micelle are investigated by UV spectrometry at the λmax value of 350 nm. The antiproliferative effect of encapsulated CPT, which is investigated in A549 cells, suggests that ε-cp-co-CA may be a promising anticancer drug carrier.

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Publication details

The article was received on 22 Feb 2018, accepted on 09 May 2018 and first published on 10 May 2018


Article type: Paper
DOI: 10.1039/C8NJ00901E
Citation: New J. Chem., 2018, Accepted Manuscript
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    Natural Solvent-Assisted Synthesis of Amphiphilic Co-Polymeric Nanomicelle for Prolonged Release of Camptothecin Delivery

    M. Rajan, P. Pradeep Kumar, A. M. Elgorban and A. H. Bahkali, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ00901E

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