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Surface immobilization of Biotin-DNA conjugates on polystyrene beads via SPAAC for biological interaction and cancer theranostic application

Abstract

Abstract: Surface immobilization of DNA conjugates via SPAAC for cancer theranostic application reported here. The formation of DNA conjugates was supported by absorption and emission studies. The luminescent DNA conjugates exhibited high potency and high selectivity in cancerous HeLa and MCF7 cells than normal kidney cell. The bright red fluorescence from these types of surface modified polystyrene beads in the HeLa cells make these conjugates suitable for deep tissue imaging. These conjugates also showed remarkable binding efficiency with CT-DNA and protein BSA which can demonstrate the mode of action in cancer cells.

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Publication details

The article was received on 17 Feb 2018, accepted on 09 Apr 2018 and first published on 17 Apr 2018


Article type: Paper
DOI: 10.1039/C8NJ00814K
Citation: New J. Chem., 2018, Accepted Manuscript
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    Surface immobilization of Biotin-DNA conjugates on polystyrene beads via SPAAC for biological interaction and cancer theranostic application

    P. Paira, B. MV, S. De, L. Thilak Babu, S. Maiti, B. Sarkar and A. S.K. Kumar, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ00814K

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