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Gold–chitosan composite with low symmetry zinc phthalocyanine for enhanced singlet oxygen generation and improved photodynamic therapy activity

Abstract

Novel zinc(II) 3-(4-((3,17,23-tris(4-(benzo[d]thiazol-2-yl) phenoxy) phthalocyanine-9-yl)oxy)phenyl)propanoic acid (complex 3) was synthesised. Complex 3 was subsequently interacted with gold nanoparticles (AuNPs), chitosan (CT) and gold–chitosan (AuCT) hybrid to form 3–AuNPs, 3–CT and 3–AuCT, respectively. The conjugates afforded a decrease in fluorescence quantum yield with corresponding increase in triplet and singlet quantum yields compared to complex 3. The in vitro dark cytotoxicity and photodynamic therapy activity (PDT) of complex 3 and 3–AuCT composites were investigated against epithelial breast cancer cells (MCF–7) with both samples showing relatively no dark cytotoxicity activity. They both accounted for cell viability ≥ 90% at concentration ≤ 59.2 µg/mL. 3-AuCT showed better PDT activity (compared to 3 alone) with less than 50% viable cells at concentration ≥ 29.6 µg/mL making it potentially applicable for PDT. On the other hand, AuCT displayed some activity against cancer cells, probably due to photothermal activity since gold is a light absober, however it had more than 50% viable cells at concentration ≤ 59.2 µg/mL.

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Publication details

The article was received on 16 Feb 2018, accepted on 03 May 2018 and first published on 04 May 2018


Article type: Paper
DOI: 10.1039/C8NJ00801A
Citation: New J. Chem., 2018, Accepted Manuscript
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    Gold–chitosan composite with low symmetry zinc phthalocyanine for enhanced singlet oxygen generation and improved photodynamic therapy activity

    E. Dube, D. O. Oluwole, E. Prinsloo and T. Nyokong, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ00801A

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