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Delivery of coumarin-containing all-trans retinoic acid derivative via targeted nanoparticles encapsulating indocyanine green for chemo/photothermal/photodynamic therapy of breast cancer

Abstract

Developing the chemo/photothermal/photodynamic therapy with nanoplatforms offers a promising strategy for effective cancer treatment. Recently, all-trans retinoic acid (ATRA), as a potential antitumor drug, has drawn great attention in improving its antitumor activity. In this study, a novel coumarin-containing ATRA (AC) and indocyanine green (ICG) dye loaded nanoparticles, with the targeted ligand cyclic (Arg-Gly-Asp-D-Phe-Lys) (cRGD) peptide, were fabricated by self-assembling, as a new theranostic nanoplatform for chemo/photothermal/photodynamic therapy. The formed nanoparticles (AC/ICG-TNPs) had a diameter of around 133 nm with uniform monodispersity. Additionally, AC/ICG-TNPs showed marked stability under the normal physiological conditions. However, it could rapidly release drug under the mild acidic microenvironment. Moreover, confocal microscopy observations confirmed that the uptake of AC/ICG-TNPs increased in the breast cancer cells, especially in MDA-MB-231 cells, probably mediated by cRGD via specific recognition of the overexpressed integrin αvβ3. Meanwhile, free AC exhibited stronger cytotoxic effects than free ATRA in MTT assay, and AC/ICG-TNPs were demonstrated to possess the excellent antitumor efficacy when exposed to NIR irradiation through the combination therapy. Hence, this designed therapeutic method is a good candidate for the improved bioactivity of ATRA and the site-specific combinational therapy against breast cancer.

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Publication details

The article was received on 02 Feb 2018, accepted on 11 Apr 2018 and first published on 11 Apr 2018


Article type: Paper
DOI: 10.1039/C8NJ00578H
Citation: New J. Chem., 2018, Accepted Manuscript
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    Delivery of coumarin-containing all-trans retinoic acid derivative via targeted nanoparticles encapsulating indocyanine green for chemo/photothermal/photodynamic therapy of breast cancer

    J. Jiao, H. Wu, F. Chen, R. Chen, B. Sun and M. Wang, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ00578H

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