Revisit of 1 Chloro-1,2-benziodoxol-3-one: Efficient ortho-Chlorination of aryls under aqueous conditions.
Abstract
The application of 1-chloro-1,2-benziodoxol-3-one as a powerful chlorinating agent on aniline derivatives is explored. The amide directing group assisted radical mediated ortho-selective chlorination proceeds in the absence of radical initiator. Various electronically differentiated anilides and sulfonamides are tolerated under aqueous conditions.