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Issue 12, 2018
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Redox/ultrasound dual stimuli-responsive nanogel for precisely controllable drug release

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Abstract

Ultrasound is expected to be utilized in stimuli-responsive drug delivery systems (DDS) since it is safe, non-invasive and easy to control. In this study, a novel nanogel system with a redox/ultrasound dual stimuli-response has been developed for precise control of drug release. First, a thermo-sensitive copolymer PEIm–PNIPAMn–PEIm self-assembled into micelles in aqueous solution above its LCST. Then, PEI gel shell was formed by using a disulfide-containing cross-linker and spherical nanogels were obtained. Perfluorohexane (PFH) was introduced into the nanogels to provide a cavitation effect under an ultrasound stimulus. Furthermore, the PEI gel shell was specifically disintegrated by glutathione (GSH). The effects of redox/ultrasound on the structure and drug release of the nanogels were investigated. The release rate was found to be accelerated by the above-mentioned factors and a complete release was realized almost instantly. The release mechanism of the nanogels was then investigated. The dual stimuli-responsive nanogels present a promising application prospect for precisely controllable drug delivery/release.

Graphical abstract: Redox/ultrasound dual stimuli-responsive nanogel for precisely controllable drug release

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Publication details

The article was received on 23 Jan 2018, accepted on 11 Apr 2018 and first published on 12 Apr 2018


Article type: Paper
DOI: 10.1039/C8NJ00392K
Citation: New J. Chem., 2018,42, 9472-9481
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    Redox/ultrasound dual stimuli-responsive nanogel for precisely controllable drug release

    N. Shen, B. Lei, Y. Wang, S. Xu and H. Liu, New J. Chem., 2018, 42, 9472
    DOI: 10.1039/C8NJ00392K

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