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Redox/Ultrasound Dual Stimuli-Responsive Nanogel for Precisely Controllable Drug Release

Abstract

Ultrasound is expected to be served in stimuli-responsive drug delivery system (DDS) due to its safety, non-invasion and easy to control. In this paper, a novel nanogel system with redox/ultrasound dual stimuli-response has been developed for precise control of drug release. Firstly, thermo-sensitive copolymer PEIm-PNIPAMn-PEIm could self-assemble into micelles in aqueous solution above its LCST. Then PEI gel shell was formed by using a disulfide-containing cross-linker and spherical nanogels were obtained. Perfluorohexane (PFH) was introduced into the nanogels and could provide a cavitation effect under ultrasound stimulus. Meanwhile, the PEI gel shell could be specifically disintegrated by glutathione (GSH). The effects of redox/ultrasound on the structure and drug release of the nanogels were investigated. The release rate was found to be accelerated by above-mentioned factors and a complete release was realized almost instantly. The release mechanism of the nanogels was then discussed. The dual stimuli-responsive nanogels presented a promising application prospect for precisely controllable drug delivery/release.

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Publication details

The article was received on 23 Jan 2018, accepted on 11 Apr 2018 and first published on 12 Apr 2018


Article type: Paper
DOI: 10.1039/C8NJ00392K
Citation: New J. Chem., 2018, Accepted Manuscript
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    Redox/Ultrasound Dual Stimuli-Responsive Nanogel for Precisely Controllable Drug Release

    N. Shen, B. Lei, Y. Wang, S. Xu and H. Liu, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ00392K

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