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The Correlation between Multiple Variable Factors and Autocatalytic Property of Cerium Oxide Nanoparticles based on Cell Viability

Abstract

CeO2 nanoparticles (Ce NPs) have received considerable interest due to their unique autocatalytic property. In this paper, the autocatalytic properties of three different sizes of Ce NPs were measured in vitro human gastric cancer cell line (BGC-803) at different concentrations ranging from 20 ng/μL to 200 ng/μL. The evaluation model of autocatalytic property of Ce NPs was built by partial least squares regression (PLSR) based on Matlab software. Multiple variable factors were quantitatively analyzed in terms of regression and correlation. The model indicated that the concerntration was the primary factor, followed by the size of the Ce NPs. The autocatalytic properties of Ce NPs also promoted by the specific surface area, the valence states of Ce, and the surface charge in the cell culture medium. This study attempted to establish a quantitative famework and supply a new strategy for evaluating the autocatalytic property of cerium oxide nanoparticles for their use in biological and medical fields.

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Publication details

The article was received on 17 Jan 2018, accepted on 04 May 2018 and first published on 08 May 2018


Article type: Paper
DOI: 10.1039/C8NJ00293B
Citation: New J. Chem., 2018, Accepted Manuscript
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    The Correlation between Multiple Variable Factors and Autocatalytic Property of Cerium Oxide Nanoparticles based on Cell Viability

    C. Li, X. Shi, B. Bao, J. Yan, G. Alatan and J. Zhang, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ00293B

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