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Issue 7, 2018
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Synthesis and bioapplication of a highly selective and sensitive fluorescent probe for HOCl based on a phenothiazine–dicyanoisophorone conjugate with large Stokes shift

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Abstract

Herein, a fluorescent probe, Dcp-EPtz, for HOCl based on a strong push–pull phenothiazine–dicyanoisophorone conjugate was prepared. The probe exhibits a very large Stokes shift of over 170 nm. Dcp-EPtz turns out to be a fast-responsive (<10 s) fluorescent probe for HOCl with high selectivity and sensitivity. It shows a good linear relationship between the enhanced fluorescence intensity at 617 nm and the concentration of hypochlorous acid in the range 0–10 μM, with the detection limit of 3.9 × 10−8 M. Moreover, the probe Dcp-EPtz exhibits the ability for endogenous HOCl monitoring in living cells.

Graphical abstract: Synthesis and bioapplication of a highly selective and sensitive fluorescent probe for HOCl based on a phenothiazine–dicyanoisophorone conjugate with large Stokes shift

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Publication details

The article was received on 17 Jan 2018, accepted on 21 Feb 2018 and first published on 21 Feb 2018


Article type: Paper
DOI: 10.1039/C8NJ00279G
Citation: New J. Chem., 2018,42, 5135-5141
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    Synthesis and bioapplication of a highly selective and sensitive fluorescent probe for HOCl based on a phenothiazine–dicyanoisophorone conjugate with large Stokes shift

    D. Zheng, X. Qiu, C. Liu, X. Jiao, S. He, L. Zhao and X. Zeng, New J. Chem., 2018, 42, 5135
    DOI: 10.1039/C8NJ00279G

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