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Study of interactions of mononucleotides with 1,4-dihydropyridine vesicles using NMR and ITC techniques

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Abstract

The use of 1,4-dihydropyridine (DHP) vesicles as drug delivery agents can improve the diffusion of nucleoside and nucleotide prodrugs through the cellular membrane without degradation. Different NMR studies: spin–lattice relaxation in the rotating frame (T1ρ), saturation transfer double difference (STDD), 1H NMR chemical shift titration, as well as isothermal titration calorimetry (ITC) experiments, showed that mononucleotides bind to 1,4-DHP vesicles. The influence of the structure of the mononucleotides as well as that of the derivatives of 1,4-DHP on the complexation parameters was studied.

Graphical abstract: Study of interactions of mononucleotides with 1,4-dihydropyridine vesicles using NMR and ITC techniques

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Publication details

The article was received on 10 Jan 2018, accepted on 20 Mar 2018 and first published on 21 Mar 2018


Article type: Paper
DOI: 10.1039/C8NJ00160J
Citation: New J. Chem., 2018, Advance Article
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    Study of interactions of mononucleotides with 1,4-dihydropyridine vesicles using NMR and ITC techniques

    R. Muhamadejev, M. Petrova, R. Smits, A. Plotniece, K. Pajuste, G. Duburs and E. Liepinsh, New J. Chem., 2018, Advance Article , DOI: 10.1039/C8NJ00160J

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