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Core-shell structured NiCo@Pt/C nanocomposite modified sensor for the voltammetric determination of pseudoephedrine HCl

Abstract

Core-shell structured NiCo@Pt/C nanocomposite was developed for the determination of pseudoephedrine HCl (PSE) in drug samples. Different NiCo@Pt/C nanomaterials were fabricated depending on Ni:Co atomic ratio using ethylene glycol as the reducing agent in an assisted microwave irradiation process. X-ray diffraction (XRD) and transmission electron microscopy (TEM) were conducted to characterize the prepared nanocomposite. The electrocatalytic activity of NiCo@Pt/C nanocomposite for determining PSE was demonstrated using cyclic voltammetry, linear sweep voltammetry, differential pulse voltammetry and electrochemical impedance spectroscopy. PSE oxidation current density value was efficiently affected by cobalt content in fabricated NiCo@Pt/C nanocomposite. The maximum activity was achieved at the nanomaterial containing Ni:Co atomic ratio of 1:3. Differential pulse voltammetry indicated a linear dependence of oxidation current density on PSE concentration up to 1400 M. High sensitivity, good reproducibility and stability were displayed by NiCo@Pt/C nanocomposite during the estimation of PSE. This would encourage its wide application in the clinical assaying of the studied drug.

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Publication details

The article was accepted on 02 Jan 2018 and first published on 02 Jan 2018


Article type: Paper
DOI: 10.1039/C7NJ04973K
Citation: New J. Chem., 2018, Accepted Manuscript
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    Core-shell structured NiCo@Pt/C nanocomposite modified sensor for the voltammetric determination of pseudoephedrine HCl

    R. M. Abdel Hameed, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C7NJ04973K

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