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Issue 5, 2018
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A cationic cyclodextrin clicked bilayer chiral stationary phase for versatile chiral separation in HPLC

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Abstract

A cationic cyclodextrin (CD) clicked bilayer chiral stationary phase (CSP) was developed via click chemistry for chiral separations in multimode high-performance chromatography (HPLC). The versatility of this new CSP was evaluated using 17 model racemic pairs including aromatic alcohols, flavonoids and isoxazoline enantiomers in both reversed-phase (RP) and normal-phase (NP) HPLC. The CD functionality-enhanced chiral selectivity was elucidated in different elution modes. Higher chiral resolutions were shown in the RP-elution mode due to the inclusion complexation in comparison to the NP-elution mode. The highest chiral resolution of 4.40 was achieved for 4ClPh-OPr, with 12 racemic pairs baseline separated in RP-HPLC. The addition of organic modifiers in mobile phases plays an important role in optimizing the enantioselectivities of the cationic CD bilayer CSP in NP-HPLC.

Graphical abstract: A cationic cyclodextrin clicked bilayer chiral stationary phase for versatile chiral separation in HPLC

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Publication details

The article was received on 14 Dec 2017, accepted on 19 Jan 2018 and first published on 22 Jan 2018


Article type: Paper
DOI: 10.1039/C7NJ04960A
Citation: New J. Chem., 2018,42, 3526-3533
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    A cationic cyclodextrin clicked bilayer chiral stationary phase for versatile chiral separation in HPLC

    J. Zhou, B. Yang, J. Tang and W. Tang, New J. Chem., 2018, 42, 3526
    DOI: 10.1039/C7NJ04960A

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