Issue 5, 2018

Oxone-mediated annulation of 2-aminobenzamides and 1,2-diaminobenzenes with sec-amines via imine-N-oxides: new syntheses of 2,3-dihydroquinazolin-4(1H)-ones and 1H-benzimidazoles

Abstract

An efficient and mild method for the preparation of 2,3-dihydroquinazolin-4(1H)-ones and 1H-benzimidazoles by the oxone-mediated reaction of sec-amines via imine-N-oxides with 2-amino-N-substituted benzamides and 1,2-diaminobenzenes respectively in THF–water (2 : 1) at ambient temperature is described.

Graphical abstract: Oxone-mediated annulation of 2-aminobenzamides and 1,2-diaminobenzenes with sec-amines via imine-N-oxides: new syntheses of 2,3-dihydroquinazolin-4(1H)-ones and 1H-benzimidazoles

Supplementary files

Article information

Article type
Letter
Submitted
13 Dec 2017
Accepted
01 Feb 2018
First published
01 Feb 2018

New J. Chem., 2018,42, 3188-3191

Oxone-mediated annulation of 2-aminobenzamides and 1,2-diaminobenzenes with sec-amines via imine-N-oxides: new syntheses of 2,3-dihydroquinazolin-4(1H)-ones and 1H-benzimidazoles

V. Sriramoju, S. Kurva and S. Madabhushi, New J. Chem., 2018, 42, 3188 DOI: 10.1039/C7NJ04939K

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