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Synthesis of Benzyl Hydrazine Derivatives via Amination of Benzylic C (sp3)–H Bonds with Dialkyl Azodicarboxylates

Abstract

A novel synthesis of benzyl hydrazines through oxidative amination of benzylic C−H bonds has been developed. The resulting aminated products are accessed directly from the reaction of alkylarenes with dialkyl azodicarboxylates using Cu2O/Phen as catalytic system. The protocol proceeded smoothly and a decent range of N-alkylated hydrazides were synthesized in acceptable to good yields. Both primary and secondary sp3 C–H sources afford only monoamination

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Publication details

The article was received on 10 Dec 2017, accepted on 11 Feb 2018 and first published on 12 Feb 2018


Article type: Paper
DOI: 10.1039/C7NJ04880G
Citation: New J. Chem., 2018, Accepted Manuscript
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    Synthesis of Benzyl Hydrazine Derivatives via Amination of Benzylic C (sp3)–H Bonds with Dialkyl Azodicarboxylates

    A. Samzadeh-Kermani, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C7NJ04880G

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