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Synthesis, structural characterization, biological evaluation and molecular docking studies of new platinum(II) complexes bearing isocyanides

Abstract

New Pt(II) complexes [R'2Pt(CNR)2] (1a–c; R' = Me and 2a–c; R' = p-tolyl) were synthesized by the reaction of the precursor complexes cis,cis-[Me2Pt(µ-SMe2)2PtMe2], A, and cis-[(p-tolyl)2Pt(SMe2)2], B, with four or two equivalent of different types of isocyanide ligands (CNR; R = a; t-butyl, b; benzyl, c; cyclohexyl isocyanide), respectively. All complexes were characterized by FT-IR, NMR spectroscopies and the structure of 2b was confirmed by single crystal X-ray determination. An in vitro cytotoxicity evaluation against three human cancer cell lines including A549 (nonsmall cell lung cancer), SKOV3 (human ovarian cancer) and MCF-7 (human breast cancer) bear promising antitumor activities of 1b and 2a in comparison with the standard cisplatin. Also, 1b effectively furnished apoptosis-inducing activities to MCF-7 cancer cell line. The electrophoresis mobility shift assays on plasmid as well as molecular docking studies on DNA structures effectively revealed the specific binding site, binding mode and the best orientation of the complexes to DNA.

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Publication details

The article was received on 06 Dec 2017, accepted on 02 Apr 2018 and first published on 04 Apr 2018


Article type: Paper
DOI: 10.1039/C7NJ04819J
Citation: New J. Chem., 2018, Accepted Manuscript
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    Synthesis, structural characterization, biological evaluation and molecular docking studies of new platinum(II) complexes bearing isocyanides

    M. fereidoonnezhad, H. R. Shahsavari, S. abedanzadeh, A. Nezafati, A. Khazali, P. Mastrorilli, M. Babaghasabha, Z. faghih, Z. Faghih, S. Bahemmat and M. H. Beyzavi, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C7NJ04819J

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