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Issue 4, 2018
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Fluorescent protein nanovessels packing DNA into a nucleosome-like gene carrier

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Abstract

We describe here a new type of DNA scaffold called fluorescent protein nanovessels (FPNs). This protein-based fluorescent material can recognize DNA and pack DNA into nucleosome-like structures, which partially resembles DNA assembly in vivo. The DNA recognizing FPNs showed excellent fluorescence properties, high biocompatibility, and can be readily internalized by yeast cells. Importantly, FPNs can serve as gene carriers that deliver functional DNA into the cells. We expect that FPNs will be a good platform to study DNA assembly and packing as well as a new carrier system to deliver genes.

Graphical abstract: Fluorescent protein nanovessels packing DNA into a nucleosome-like gene carrier

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Publication details

The article was received on 03 Dec 2017, accepted on 10 Jan 2018 and first published on 10 Jan 2018


Article type: Paper
DOI: 10.1039/C7NJ04750A
Citation: New J. Chem., 2018,42, 2776-2781
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    Fluorescent protein nanovessels packing DNA into a nucleosome-like gene carrier

    Z. Li, X. Wang, Z. Tian and Z. Chen, New J. Chem., 2018, 42, 2776
    DOI: 10.1039/C7NJ04750A

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