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Issue 7, 2018
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Protein-mediated mineralization of edaravone into injectable, pH-sensitive microspheres used for potential minimally invasive treatment of osteomyelitis

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Abstract

Osteomyelitis, an infection within bone, is difficult to treat. Conventional surgical treatment causes severe pain in the patients physically and mentally. There is an urgent need to develop injectable nano- and/or micro-medicine for minimally invasive treatment of osteomyelitis. In this study, we provide a facile protocol of protein-mediated mineralization of edaravone into injectable, pH-sensitive CaCO3 microspheres used for potential minimally invasive treatment of osteomyelitis. The mineral part of the composite microspheres is used to neutralize the acidic environment caused by bacterial infection. At the same time, edaravone encapsulated in CaCO3 microspheres is released to resist oxidative stress. The drug loading efficiency (DLE) and the drug loading content (DLC) are 89.4% and 19.2%, respectively. Our results demonstrate that the prepared microspheres can protect and promote the proliferation and differentiation of osteoblasts under stimulation of H2O2 at lower pH.

Graphical abstract: Protein-mediated mineralization of edaravone into injectable, pH-sensitive microspheres used for potential minimally invasive treatment of osteomyelitis

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Publication details

The article was received on 04 Dec 2017, accepted on 23 Feb 2018 and first published on 23 Feb 2018


Article type: Paper
DOI: 10.1039/C7NJ04745B
Citation: New J. Chem., 2018,42, 5447-5455
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    Protein-mediated mineralization of edaravone into injectable, pH-sensitive microspheres used for potential minimally invasive treatment of osteomyelitis

    J. Zhang, M. Zhao, X. Tian, X. Lv, Z. Chen, K. Zhou, X. Ren, P. Zhang and X. Mei, New J. Chem., 2018, 42, 5447
    DOI: 10.1039/C7NJ04745B

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