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A camphor based 1,3-diamine Ru(II) terpyridine complex: synthesis, characterization, kinetic investigation and DNA binding

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Abstract

The synthesis and reactivity of a new ruthenium(II) terpyridine complex with a bidentate enantiopure camphor based diamine ligand is described. Reactivity measurements of the Ru(II) complex showed a high affinity towards guanosine-5′-monophosphate as a model for DNA bases. Furthermore, the Ru(II) complex was found to interact with CT-DNA. This suggests the high potential of the newly synthesized ruthenium complex as an antitumor agent.

Graphical abstract: A camphor based 1,3-diamine Ru(ii) terpyridine complex: synthesis, characterization, kinetic investigation and DNA binding

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Publication details

The article was received on 29 Nov 2017, accepted on 24 Jan 2018 and first published on 05 Feb 2018


Article type: Letter
DOI: 10.1039/C7NJ04674J
Citation: New J. Chem., 2018, Advance Article
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    A camphor based 1,3-diamine Ru(II) terpyridine complex: synthesis, characterization, kinetic investigation and DNA binding

    M. M. Milutinović, Ž. D. Bugarčić and R. Wilhelm, New J. Chem., 2018, Advance Article , DOI: 10.1039/C7NJ04674J

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