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Issue 7, 2018
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One-step esterification of nanocellulose in a Brønsted acid ionic liquid for delivery to glioblastoma cancer cells

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Abstract

The Fisher esterification reaction has been exploited for linking a peptide (chlorotoxin) onto the surface of nanocellulose using a Brønsted acid ionic liquid both as a solvent and a catalyst. Indeed, cellulose nanocrystals were functionalized with the peptide thanks to a mild, one-step and organic solvent-free reaction. The obtained nanocellulose showed excellent properties in terms of biocompatibility and internalization in the U87MG glioblastoma cell line, thus demonstrating the possible use of this material as a novel drug delivery carrier.

Graphical abstract: One-step esterification of nanocellulose in a Brønsted acid ionic liquid for delivery to glioblastoma cancer cells

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Publication details

The article was received on 27 Nov 2017, accepted on 17 Feb 2018 and first published on 19 Feb 2018


Article type: Paper
DOI: 10.1039/C7NJ04633B
Citation: New J. Chem., 2018,42, 5237-5242
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    One-step esterification of nanocellulose in a Brønsted acid ionic liquid for delivery to glioblastoma cancer cells

    L. Cellante, R. Costa, I. Monaco, G. Cenacchi and E. Locatelli, New J. Chem., 2018, 42, 5237
    DOI: 10.1039/C7NJ04633B

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