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Phase partitioning, solvent-switchable BODIPY probes for high contrast cellular imaging and FCS

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Abstract

Lipophilic BODIPY fluorphores, in which the BODIPY core bears pendant dipyrido[3,2-a:2′,3′-c]phenazine (Dppz) or naphthyridyl and cholesterol substituents were designed and prepared as lipid probes for both liposomes and live cell imaging. The probes are non-emissive in water but permeate both GUV and live cell membranes and provide high contrast fluorescence and lifetime imaging of membranous structures and lipid droplets in cells and are suitable for FCS measurements on lipid membranes.

Graphical abstract: Phase partitioning, solvent-switchable BODIPY probes for high contrast cellular imaging and FCS

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Publication details

The article was received on 24 Nov 2017, accepted on 29 Jan 2018 and first published on 31 Jan 2018


Article type: Paper
DOI: 10.1039/C7NJ04604A
Citation: New J. Chem., 2018, Advance Article
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    Phase partitioning, solvent-switchable BODIPY probes for high contrast cellular imaging and FCS

    D. O’Connor, A. Byrne, C. Dolan and T. E. Keyes, New J. Chem., 2018, Advance Article , DOI: 10.1039/C7NJ04604A

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