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A Multi-component Synthesis of N-Substituted 2-Amino-3-Cyano Pyrroles via Ring-opening of Nitroepoxides

Abstract

A multi-component synthesis of N-substituted 2-amino-3-cyano pyrroles from nitroepoxides, amines and malononitrile has been demonstrated. The reaction proceeded well for a wide range of nitroepoxides and amines in a mild condition without transition metal catalysis following with three new bonds formation.

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Publication details

The article was received on 24 Nov 2017, accepted on 12 Jan 2018 and first published on 12 Jan 2018


Article type: Letter
DOI: 10.1039/C7NJ04584K
Citation: New J. Chem., 2018, Accepted Manuscript
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    A Multi-component Synthesis of N-Substituted 2-Amino-3-Cyano Pyrroles via Ring-opening of Nitroepoxides

    X. Liu, Z. Nie, J. Shao, W. Chen and Y. Yu, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C7NJ04584K

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