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Issue 4, 2018
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A multi-component synthesis of N-substituted 2-amino-3-cyano pyrroles via ring-opening of nitroepoxides

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Abstract

A multi-component synthesis of N-substituted 2-amino-3-cyano pyrroles from nitroepoxides, amines and malononitrile has been demonstrated. The reaction proceeded well for a wide range of nitroepoxides and amines under mild conditions without transition metal catalysis via the formation of three new bonds.

Graphical abstract: A multi-component synthesis of N-substituted 2-amino-3-cyano pyrroles via ring-opening of nitroepoxides

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Publication details

The article was received on 24 Nov 2017, accepted on 12 Jan 2018 and first published on 12 Jan 2018


Article type: Letter
DOI: 10.1039/C7NJ04584K
Citation: New J. Chem., 2018,42, 2368-2371
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    A multi-component synthesis of N-substituted 2-amino-3-cyano pyrroles via ring-opening of nitroepoxides

    X. Liu, Z. Nie, J. Shao, W. Chen and Y. Yu, New J. Chem., 2018, 42, 2368
    DOI: 10.1039/C7NJ04584K

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