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Issue 7, 2018
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A novel fluorescent probe for selective detection of hydrogen sulfide in living cells

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Abstract

A novel fluorescent probe for the detection of H2S in living cells was designed and synthesized by introducing 2,4-dinitrophenyl ether into a phenanthroimidazole derivative. The structures of the fluorophore and the probe were characterized using 1H NMR, 13C NMR and mass spectra. The probe shows excellent sensitivity, and the detection limit is 1.11 μM. High selectivity and competition are also revealed in corresponding studies. The probe can be applied in a wide pH range. Cellular assays indicate that the cytotoxicity of the probe is low, and the cellular permeability is good. With these desirable properties, the probe demonstrates a possible approach for investigating the biological roles of H2S in living tissues.

Graphical abstract: A novel fluorescent probe for selective detection of hydrogen sulfide in living cells

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Publication details

The article was received on 23 Nov 2017, accepted on 16 Feb 2018 and first published on 16 Feb 2018


Article type: Paper
DOI: 10.1039/C7NJ04577H
Citation: New J. Chem., 2018,42, 5185-5192
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    A novel fluorescent probe for selective detection of hydrogen sulfide in living cells

    S. Peng, T. Zhong, T. Guo, D. Shu, D. Meng, H. Liu and D. Guo, New J. Chem., 2018, 42, 5185
    DOI: 10.1039/C7NJ04577H

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