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An asynchronous-alternating merging-zone flow-injection gold nanoparticles probe method for determining anti-diabetic pioglitazone hydrochloride medicine

Abstract

Pioglitazone hydrochloride (PGH) can effectively reduce resistance of cells to the insulin, which is widely treated of diabetes type 2. This research discovered that PGH in acidic media could rapidly induce the aggregation of gold nanoparticles (AuNPs) to bring about red-to-purple color change caused by electrostatic adsorption and intermolecular hydrogen bonding. Thus, based on this principle, an automatic method with the asynchronous-alternating merging-zone was established to determine the PGH content in medicines. Our method dispensed with calculation for the absorbance ratio and spectrum scanning for two wavelengths. More importantly, the proposed method could solve these problems of unmanageable aggregating degree, big manual error, and high testing cost in common AuNPs colorimetry. The approach was rapid in sample throughput (a sample/min) under the premise consuming 30 μL reagents (8 nmol L-1 AuNPs) per time, high in repeatability (RSD ≤ 1.1%, n = 11) and has good addition recovery (99 - 104%) in 0.5 - 15 mg L-1 range which is suitable for analyzing PGH content in diabetes medicines.

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Publication details

The article was received on 19 Nov 2017, accepted on 01 Feb 2018 and first published on 01 Feb 2018


Article type: Paper
DOI: 10.1039/C7NJ04492E
Citation: New J. Chem., 2018, Accepted Manuscript
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    An asynchronous-alternating merging-zone flow-injection gold nanoparticles probe method for determining anti-diabetic pioglitazone hydrochloride medicine

    G. Zhang, Y. Li and X. Gao, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C7NJ04492E

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