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Highly antiproliferative neutral Ru(II)-arene phosphine complexes

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Abstract

Six ruthenium(II)- and four gold(I)-phosphine based complexes were synthesized and fully characterized. Some of them displayed strong antiproliferative properties for several types of cancer including colon, breast, and lung. Notably, two of the Ru(II) complexes displayed an IC50 of around 2 μM, which is exceptional for these types of complexes. The dramatic impact of the nature of the arene coordinated on the ruthenium center was clearly evidenced.

Graphical abstract: Highly antiproliferative neutral Ru(ii)-arene phosphine complexes

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Publication details

The article was received on 15 Nov 2017, accepted on 10 Jan 2018 and first published on 10 Jan 2018


Article type: Paper
DOI: 10.1039/C7NJ04442A
Citation: New J. Chem., 2018, Advance Article
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    Highly antiproliferative neutral Ru(II)-arene phosphine complexes

    F. Chotard, L. Dondaine, C. Balan, A. Bettaïeb, C. Paul, P. Le Gendre and E. Bodio, New J. Chem., 2018, Advance Article , DOI: 10.1039/C7NJ04442A

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