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Highly antiproliferative neutral Ru(II)-arene phosphine complexes

Abstract

Six ruthenium(II)- and four gold(I)-phosphine based complexes have been synthesized and fully characterized. Some of them display strong antiproliferative properties on several types of cancer including colon, breast, and lung. Notably, two of Ru(II) complexes display IC50 around 2 µM, which is exceptional for these kinds of complexes. The dramatic impact of the nature of the arene coordinated on ruthenium center was clearly evidenced.

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Publication details

The article was received on 15 Nov 2017, accepted on 10 Jan 2018 and first published on 10 Jan 2018


Article type: Paper
DOI: 10.1039/C7NJ04442A
Citation: New J. Chem., 2018, Accepted Manuscript
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    Highly antiproliferative neutral Ru(II)-arene phosphine complexes

    F. Chotard, L. Dondaine, C. Balan, A. Bettaeib, C. Paul, P. Le Gendre and E. Bodio, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C7NJ04442A

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