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Stereospecific ligands and their complexes. XXIV. Synthesis, characterization and some biological properties of Pd(II) and Pt(II) complexes with R2-S,S-eddtyr

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Abstract

Four new platinum(II) complexes of general formula [PtCl2(R2-S,S-eddtyr)] (R = ethyl, n-propyl, n-butyl and n-pentyl); S,S-eddtyr = ethylenediamine-N,N′-di-(2,2′-di(4-hydroxy)-benzyl-acetic acid) have been synthesized and characterized by microanalysis, and infrared, 1H NMR and 13C NMR spectroscopy. The in vitro antimicrobial activity of ligands L1–L4 [L = R2-S,S-eddtyr; R = ethyl (L1), n-propyl (L2), n-butyl (L3), n-pentyl (L4)], platinum(II) complexes C1–C4 [PtCl2(R2-S,S-eddtyr)] [R = ethyl (C1), n-propyl (C2), n-butyl (C3), n-pentyl (C4)] and palladium(II) complexes C5–C8 [PdCl2(R2-S,S-eddtyr)] [R = ethyl (C5), n-propyl (C6) or n-butyl (C7) or n-pentyl (C8)] was investigated. The cytotoxicity of ligands and platinum(II) complexes was investigated using MTT assay. The interaction of platinum and palladium complexes [MCl2(R2-S,S-eddtyr)] (M = Pt or Pd) with calf thymus DNA (CT-DNA) was investigated using UV-Vis absorption and fluorescence spectroscopy. The association constant (Kb) estimated from the absorption spectral study and the quenching constant (KSV) calculated from relevant fluorescence quenching data indicate a non-covalent interaction between the metal complex and DNA. Ethidium bromide (EB) competitive studies revealed that complexes C1–C8 could interact with CT-DNA through intercalation. Furthermore, the interactions between human serum albumin (HSA) and the platinum(II) and palladium(II) complexes were also investigated by UV-Vis absorption and fluorescence spectroscopy, showing that the new complexes could strongly bind with HSA.

Graphical abstract: Stereospecific ligands and their complexes. XXIV. Synthesis, characterization and some biological properties of Pd(ii) and Pt(ii) complexes with R2-S,S-eddtyr

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Publication details

The article was received on 20 Nov 2017, accepted on 25 Jan 2018 and first published on 31 Jan 2018


Article type: Paper
DOI: 10.1039/C7NJ04437B
Citation: New J. Chem., 2018, Advance Article
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    Stereospecific ligands and their complexes. XXIV. Synthesis, characterization and some biological properties of Pd(II) and Pt(II) complexes with R2-S,S-eddtyr

    D. Lj. Stojković, V. V. Jevtić, G. P. Radić, M. B. Đukić, R. M. Jelić, M. M. Zarić, M. V. Anđelković, M. S. Mišić, D. D. Baskić and S. R. Trifunović, New J. Chem., 2018, Advance Article , DOI: 10.1039/C7NJ04437B

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