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Issue 5, 2018
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An amplified platform nanostructure sensor for the analysis of epirubicin in the presence of topotecan as two important chemotherapy drugs for breast cancer therapy

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Abstract

Epirubicin (EB) and topotecan (TP) are two major anticancer drugs that are used in breast cancer therapy with many side effects. In this research, we introduce a carbon paste electrode, modified with 1-butylpyridinium hexafluorophosphate and CuO nanoparticles (CPE/1-BPr/CuO-NPs), as an amplified sensor for the electrochemical determination of EB. The electrochemical behavior of EB was initially studied on the surface of CPE/1-BPr/CuO-NPs, CPE/CuO-NPs, CPE/1-BPr, and on bare carbon paste electrodes. The CPE/1-BPr/CuO-NPs showed two separate oxidation signals with a potential of 628 mV and 935 mV in the oxidation of EB and TP, respectively; these potentials are sufficient for determining them simultaneously. The linear response range was found to be 0.03 to 800 μM (R2 = 0.9972) and 0.7 to 800 μM (R2 = 0.9984) for the EB and TP concentrations, with limits of detection (LODs) of 0.008 μM and 0.3 μM, respectively. Finally, the concentrations of EB and TP were successfully measured by CPE/1-BPr/CuO-NPs as a voltammetric sensor in real samples.

Graphical abstract: An amplified platform nanostructure sensor for the analysis of epirubicin in the presence of topotecan as two important chemotherapy drugs for breast cancer therapy

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Publication details

The article was received on 14 Nov 2017, accepted on 30 Jan 2018 and first published on 31 Jan 2018


Article type: Paper
DOI: 10.1039/C7NJ04430E
Citation: New J. Chem., 2018,42, 3828-3832
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    An amplified platform nanostructure sensor for the analysis of epirubicin in the presence of topotecan as two important chemotherapy drugs for breast cancer therapy

    S. A. R. Alavi-Tabari, M. A. Khalilzadeh, H. Karimi-Maleh and D. Zareyee, New J. Chem., 2018, 42, 3828
    DOI: 10.1039/C7NJ04430E

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