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Issue 9, 2018
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Highly efficient organocatalysts for the asymmetric aldol reaction

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Abstract

A new class of bifunctional organocatalysts containing both thiazolidine/pyrrolidine and imidazole cycles was prepared via a readily available synthetic route. The highly efficient five step methodology did not require intermediary purification and provided the compounds in high yields. The catalysts were successfully applied in the asymmetric direct aldol reaction between aromatic aldehydes and cyclic ketones in aqueous media. Aldol adducts were obtained in high yields with perfect stereoselectivities (up to >99% e.e. and >19 : 1 d.r.).

Graphical abstract: Highly efficient organocatalysts for the asymmetric aldol reaction

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Publication details

The article was received on 14 Nov 2017, accepted on 01 Apr 2018 and first published on 02 Apr 2018


Article type: Paper
DOI: 10.1039/C7NJ04424K
Citation: New J. Chem., 2018,42, 7416-7421
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    Highly efficient organocatalysts for the asymmetric aldol reaction

    C. G. Jacoby, P. H. V. Vontobel, M. F. Bach and P. H. Schneider, New J. Chem., 2018, 42, 7416
    DOI: 10.1039/C7NJ04424K

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