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Antiproliferative, antioxidant, computational and electrochemical studies of new azo-containing Schiff Base Ruthenium(II) complexes

Abstract

A new series of ruthenium (II) complexes 7-11 containing -N=N- group were synthesized and characterized by elemental analyses, IR, UV-Visible spectroscopy and 1H-13C NMR spectra. Solid state structures of 2, 6 and 9 were determined by single crystal X-ray diffraction studies. The antiproliferative activities of the schiff base ligands and their ruthenium (II) complexes were investigated in vitro against non-small cell lung cancer cells (H2126), prostate adenocarcinoma cells (PC3) and breast cancer cells (MCF7). Cell proliferation test were performed as dose-dependent assays at eight concentrations. 5-fluorouracil was used as positive control. Compounds 4 and 5 showed higher antiproliferative activities against only PC3 cells than the other synthesized compounds. Antioxidant capacities of the Schiff base ligands and their ruthenium (II) complexes were investigated in vitro tests via ferric reduction power, DPPH free radical, and ABTS cation radical scavenging activities. Radical scavenging activities of 7-11 complexes were found to be higher than BHT, BHA, and Trolox used as positive controls. The antioxidant activity of the complexes was found to be 30-150-fold higher than the ligands. According to obtained results in this study ruthenium complexes may be used as antioxidant agent in food, drug and cosmetic industries.

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Publication details

The article was received on 15 Nov 2017, accepted on 12 Jan 2018 and first published on 12 Jan 2018


Article type: Paper
DOI: 10.1039/C7NJ04420H
Citation: New J. Chem., 2018, Accepted Manuscript
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    Antiproliferative, antioxidant, computational and electrochemical studies of new azo-containing Schiff Base Ruthenium(II) complexes

    A. Inan, M. Ikiz, S. Taylan, S. Bilgin, N. Genç, K. Sayin, G. Ceyhan, M. KOSE, A. Kazancı and E. Ispir, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C7NJ04420H

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