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Clouding Behavior of Antidepressant Drug-Additive System in Ethylene Glycol/Glycerol-Water Mixed Media and their Thermodynamic Parameters at Cloud Point

Abstract

The influence of ethylene glycol (EG)/glycerol(GL)–water mixed media on clouding action of an amphiphilic drug amitriptyline hydrochloride (AMT) at a fixed pH 6.7 with inorganic salts (KF, KCl, KBr, LiCl, NaCl and NH4Cl) in selected compositions of EG–WR and GL–WR mixed media (0%, 5%, 10%, 15% and 20% of EG/GL, w/w) and their thermodynamic parameters at cloud point (CP) were studied. Experimentally determined critical micellization concentration (cmc) values (up to 25% w/w with an increment of 5% w/w) by conductivity measurement and results of dye solubilisation by UV-visible spectroscopic technique show that the micellization of AMT drug molecules is affected by an indirect, solvent-mediated mechanism with the increasing weight % of EG and GL in their binary mixture due to a diminution in the dielectric constant of mixed media. A raise in CP of AMT solution was observed with the increase in weight % of organic solvent in the mixed media in the absence and presence of the salts. The results demonstrate that CP behavior depends on the interaction of solvent with the drug micelles as well as on the hydrated/solvated radii of these inorganic salts ions. F— and Br— co-ions show prominent effect in higher weight % of the binary mixtures. sG0 values were found to be positive for all the additives whereas sH0 and TsS0 were positive except in presence of KF in 20% EG–WR mixed media. The results have been discussed by considering the solvent effect on electrostatic interaction and based on hydrated/solvated sizes of the ions.

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Publication details

The article was received on 10 Nov 2017, accepted on 05 Feb 2018 and first published on 06 Feb 2018


Article type: Paper
DOI: 10.1039/C7NJ04369D
Citation: New J. Chem., 2018, Accepted Manuscript
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    Clouding Behavior of Antidepressant Drug-Additive System in Ethylene Glycol/Glycerol-Water Mixed Media and their Thermodynamic Parameters at Cloud Point

    A. Koya and J. Gurung, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C7NJ04369D

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