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Issue 3, 2018
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Palladium-catalyzed three-component reaction for the synthesis of 3,3-disubstituted allylic alcohols with regio- and stereoselectivity

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Abstract

A novel three-component assembly of allenic alcohols, aryl iodides and 1,3-dicarbonyl compounds into 3,3-disubstituted allylic alcohols was promoted in the presence of a palladium source. A plausible mechanism through Pd0 catalysis was established to explain the regio- and stereoselectivity. Various aryl iodides and functionalized dicarbonyls were well-tolerated to afford products in good to moderate yields.

Graphical abstract: Palladium-catalyzed three-component reaction for the synthesis of 3,3-disubstituted allylic alcohols with regio- and stereoselectivity

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Publication details

The article was received on 09 Nov 2017, accepted on 18 Dec 2017 and first published on 19 Dec 2017


Article type: Paper
DOI: 10.1039/C7NJ04342B
Citation: New J. Chem., 2018,42, 1736-1739
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    Palladium-catalyzed three-component reaction for the synthesis of 3,3-disubstituted allylic alcohols with regio- and stereoselectivity

    G. Hu, J. Wang, Z. Li, Y. Liu and P. Gong, New J. Chem., 2018, 42, 1736
    DOI: 10.1039/C7NJ04342B

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