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Microwave-Assisted Dealkoxycarbonylation of α-Mono- and α,α-Disubstituted β-Keto- and α-Cyanoesters mediated by a Silica Gel Bed

Abstract

A new and alternative protocol for the classical Krapcho type reaction is reported here, involving a microwave-assisted method which replaced the typical aprotic polar solvent by a silica gel support with the adding of only few µL of DMF to improve the effect of the microwave irradiation. Such experimental procedure was successfully applied to several α-mono- and α,α-disubstituted β-ketoesters and α-cyanoalkylesters allowing the rapid isolation of the corresponding ketones and nitriles, with moderate to high yields, in short reaction time.

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Publication details

The article was received on 08 Nov 2017, accepted on 06 Jan 2018 and first published on 08 Jan 2018


Article type: Paper
DOI: 10.1039/C7NJ04340F
Citation: New J. Chem., 2018, Accepted Manuscript
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    Microwave-Assisted Dealkoxycarbonylation of α-Mono- and α,α-Disubstituted β-Keto- and α-Cyanoesters mediated by a Silica Gel Bed

    A. Guerrero-Caicedo, D. M. Soto-Matínez, R. Abonia and L. M. Jaramillo-Gómez, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C7NJ04340F

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