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Issue 7, 2018
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Designing model imino bifunctional chelators for radiopharmaceuticals – in vitro antitumor activity, photoluminescence and structural analysis

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Abstract

Five imino salicylidene based bifunctional chelators were developed in order to act as a multipurpose ligand system. The chelators, namely 5-methyl-2-(1,2,4-triazol-3-yliminomethyl)phenol, 2-(9-ethylcarbazol-3-yliminomethyl)-5-methylphenol, 2-[(2-imidazol-4-yl)ethyliminomethyl]-5-methylphenol, 2-[(2-indol-3-yl-ethyl)iminomethyl]-5-methylphenol and 2-[2-(4-hydroxyphenyl)ethyliminomethyl]-5-methylphenol, all of which contain a biological directing functional group on the imine moiety, were investigated via crystallographic and DFT structural studies. Synthesis, in vitro cell testing and photoluminescence are reported indicating specific quantum yields and the respective suitability for radiopharmaceutical development.

Graphical abstract: Designing model imino bifunctional chelators for radiopharmaceuticals – in vitro antitumor activity, photoluminescence and structural analysis

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Publication details

The article was received on 31 Oct 2017, accepted on 12 Feb 2018 and first published on 08 Mar 2018


Article type: Paper
DOI: 10.1039/C7NJ04208F
Citation: New J. Chem., 2018,42, 5193-5203
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    Designing model imino bifunctional chelators for radiopharmaceuticals – in vitro antitumor activity, photoluminescence and structural analysis

    A. Brink, R. E. Kroon, H. G. Visser, C. E. J. van Rensburg and A. Roodt, New J. Chem., 2018, 42, 5193
    DOI: 10.1039/C7NJ04208F

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