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Issue 2, 2018
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One-step eco-friendly approach for the fabrication of synergistically engineered fluorescent copper nanoclusters: sensing of Hg2+ ion and cellular uptake and bioimaging properties

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Abstract

Herein, a single-step eco-friendly synthetic method was established for the fabrication of synergistically engineered fluorescent copper nanoclusters (Cu NCs) using curcuma root (Curcuma longa L.) extract (curcuminoids) as a template. These Cu NCs are water-soluble and emitted bright blue fluorescence under UV light illumination at 365 nm. The synergistically engineered Cu NCs exhibited an emission peak at 440 nm with quantum yield of 7.2%. Due to their optical properties, a new fluorescent analytical strategy has been developed for the sensing of Hg2+ ions and used to evaluate cellular uptake and bioimaging properties on cancer cells (RIN-5F and MDAMB231) and fungal cells (Penicillium citrinum). It was interestingly observed that Hg2+ ion effectively quenched the emission peak of Cu NCs at 440 nm, which indicates that Cu NCs act as a fluorescent sensor. Taking advantage of this, a novel fluorescent Hg2+ sensor has been established, which showed a linear range of 0.0005–25 μM with a detection limit of 0.12 nM at room temperature. Furthermore, Cu NCs exhibited good selectivity for Hg2+ against other inorganic species, and the potentiality of the method was demonstrated by detecting Hg2+ ions in water samples. Furthermore, Cu NCs act as probes for imaging of two cancer cells (RIN-5F and MDAMB231) and fungal cells (Penicillium citrinum), and the cell viability results reveals their nontoxic nature.

Graphical abstract: One-step eco-friendly approach for the fabrication of synergistically engineered fluorescent copper nanoclusters: sensing of Hg2+ ion and cellular uptake and bioimaging properties

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Publication details

The article was received on 19 Oct 2017, accepted on 13 Dec 2017 and first published on 13 Dec 2017


Article type: Paper
DOI: 10.1039/C7NJ04031H
Citation: New J. Chem., 2018,42, 1510-1520
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    One-step eco-friendly approach for the fabrication of synergistically engineered fluorescent copper nanoclusters: sensing of Hg2+ ion and cellular uptake and bioimaging properties

    J. R. Bhamore, B. Deshmukh, V. Haran, S. Jha, R. K. Singhal, N. Lenka, S. K. Kailasa and Z. V. P. Murthy, New J. Chem., 2018, 42, 1510
    DOI: 10.1039/C7NJ04031H

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