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Issue 2, 2018
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Dihydro-2H-thiopyran-3(4H)-one-1,1-dioxide – a versatile building block for the synthesis of new thiopyran-based heterocyclic systems

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Abstract

Three series of new cyclic sulfones have been prepared by a one-pot multi-component reaction (MCR) starting from the readily available dihydro-2H-thiopyran-3(4H)-one-1,1-dioxide. The in silico screening of the synthesized compounds revealed their high anti-inflammatory, antiarthritic, antiasthmatic and antiallergic potential coupled with the strong probability levels of cystinyl aminopeptidase inhibition. The key structures were confirmed by 2D NMR techniques.

Graphical abstract: Dihydro-2H-thiopyran-3(4H)-one-1,1-dioxide – a versatile building block for the synthesis of new thiopyran-based heterocyclic systems

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Publication details

The article was received on 08 Oct 2017, accepted on 15 Dec 2017 and first published on 18 Dec 2017


Article type: Paper
DOI: 10.1039/C7NJ03846A
Citation: New J. Chem., 2018,42, 1403-1412
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    Dihydro-2H-thiopyran-3(4H)-one-1,1-dioxide – a versatile building block for the synthesis of new thiopyran-based heterocyclic systems

    V. A. Palchykov, R. M. Chabanenko, V. V. Konshin, V. V. Dotsenko, S. G. Krivokolysko, E. A. Chigorina, Y. I. Horak, R. Z. Lytvyn, A. A. Vakhula, M. D. Obushak and A. V. Mazepa, New J. Chem., 2018, 42, 1403
    DOI: 10.1039/C7NJ03846A

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