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A one-step synthesized acridine-based fluorescent chemosensor for selective detection of copper(II) ions and living cell imaging

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Abstract

Herein, the easily approachable N,N′-(acridine-3,6-diyl)dipicolinamide (ACC) prepared by only one step was evaluated as an efficient and selective chemosensor for the selective detection of copper ions (Cu2+). The fluorescence sensing behavior of ACC toward metal cations was investigated in an HEPES buffer aqueous solution. The fluorescence emission was significantly quenched in the presence of Cu2+ cations, whereas other metal cations showed a low interference. The limit of detection was found to be 1.2 × 10−7 M. The recognizing mechanism of ACC towards Cu2+ has been investigated by 1H NMR, HR-MS analysis, and density functional theory (DFT) calculations. Moreover, this sensor was verified to have low cytotoxicity and good imaging characteristics for Cu2+ in living cells; this suggested that ACC was a potential probe for the detection of Cu2+ in vivo.

Graphical abstract: A one-step synthesized acridine-based fluorescent chemosensor for selective detection of copper(ii) ions and living cell imaging

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Publication details

The article was received on 21 Sep 2017, accepted on 17 Nov 2017 and first published on 20 Nov 2017


Article type: Paper
DOI: 10.1039/C7NJ03615A
Citation: New J. Chem., 2018, Advance Article
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    A one-step synthesized acridine-based fluorescent chemosensor for selective detection of copper(II) ions and living cell imaging

    Q. Dai, H. Liu, C. Gao, W. Li, C. Zhu, C. Lin, Y. Tan, Z. Yuan and Y. Jiang, New J. Chem., 2018, Advance Article , DOI: 10.1039/C7NJ03615A

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