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Silver-catalyzed synthesis of pyrrolopiperazine fused with oxazine/imidazole via a domino approach: evaluation of anti-cancer activity

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Abstract

Silver-catalyzed domino synthesis of pyrrolopiperazine fused with oxazine/imidazole by the reaction of pyrrole-derived δ-alkynyl aldehydes and nucleophilic amines was performed. This domino strategy involves the formation of two new C–N bonds and one C–O/C–N bond, resulting in the formation of two new interesting fused heterocycles. Some of the synthesized compounds exhibit promising growth inhibitory activity against leukemia and breast cancer cell lines.

Graphical abstract: Silver-catalyzed synthesis of pyrrolopiperazine fused with oxazine/imidazole via a domino approach: evaluation of anti-cancer activity

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Publication details

The article was received on 21 Sep 2017, accepted on 24 Nov 2017 and first published on 29 Nov 2017


Article type: Letter
DOI: 10.1039/C7NJ03608F
Citation: New J. Chem., 2018, Advance Article
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    Silver-catalyzed synthesis of pyrrolopiperazine fused with oxazine/imidazole via a domino approach: evaluation of anti-cancer activity

    K. Shiva Kumar, N. P. Kumar, B. Rajesham, G. Kishan, S. Akula and R. K. Kancha, New J. Chem., 2018, Advance Article , DOI: 10.1039/C7NJ03608F

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