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Synthesis of α-glycosidase hybrid nano-flowers and their application for enriching and screening α-glycosidase inhibitors

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Abstract

To rapidly and accurately screen compounds present in traditional Chinese herbal medicines for α-glycosidase inhibitors, we synthesized a novel nano-affinity material to enable the targeted screening and enrichment of α-glycosidase inhibitors. This nano-affinity material was synthesized by self-assembly involving α-glycosidase and Cu2+. A systematic analysis revealed the flower-like structure of this nano-material, with a diameter of 7.564 μm. The highest enzyme activity was 214.03% compared to free enzymes. This novel material was used to screen and enrich α-glycosidase inhibitors from Chinese rhubarb. Ten compounds were detected. Of these, L-epicatechin and anthraquinone displayed inhibitory activity. This novel nano-hybrid affinity material allows the rapid screening and separation of active components in complex systems.

Graphical abstract: Synthesis of α-glycosidase hybrid nano-flowers and their application for enriching and screening α-glycosidase inhibitors

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Publication details

The article was received on 19 Sep 2017, accepted on 23 Nov 2017 and first published on 24 Nov 2017


Article type: Paper
DOI: 10.1039/C7NJ03545D
Citation: New J. Chem., 2018, Advance Article
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    Synthesis of α-glycosidase hybrid nano-flowers and their application for enriching and screening α-glycosidase inhibitors

    K. Qian, H. Wang, J. Liu, S. Gao, W. Liu, X. Wan, Y. Zhang, Q. Liu and X. Yin, New J. Chem., 2018, Advance Article , DOI: 10.1039/C7NJ03545D

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